A Study on Evaluation of Analgesic Potential of Newly Synthesized Compounds
Author(s):
Kirasur. B. N., Jayashri B Uppin
Keywords:
Ligands, Analgesic, Pain, Natural products, Opioids, Buprenorphine.
Abstract
While conventional pain management methods are losing their efficacy, a growing body of pharmacological research suggests that natural products may be useful in the creation of novel compounds or treatments. Moreover, recently, there has been an increasing interest to find new and analgesic drugs with possibly fewer side effects from natural sources and medicinal plants. Hence, we aimed to evaluate the analgesic activities of newly synthesized ligands from natural sources. The measurement of analgesics activity of newly synthesized ligands was performed using hot plate method in experimental animal model study. A total of 28 female Sprague-Dawley rats were equally divided in to seven group (n=4) viz. Group 1 to Group VII. Group I and Group II served as normal control and positive control group wherein animals received normal saline (10ml/kg; orally) and Buprenorphine (0.05mg/kg; i.p.) respectively. Animals in Group III, IV, V, VI, and VII received ligands L3 or L4, L3 or L4 + Zn, L3 or L4 + Ni, L3 or L4 + Cu, L3 or L4 + Co respectively. Results revealed that animals treated with ligands either L3 or L4 compounds exhibited significant analgesic activities (p<0.05). Furthermore, the results indicates that tested compound L3 and L4 both works similar to well-established drug Buprenorphine. Both L3 and L4 exhibited moderate analgesic activity at 30 mins and activity was increased at 60min and reached the maximum peak at 180min. In conclusion, significant analgesic activities of newly synthesized ligands L3 and L4 was observed, and hence these ligands could be explored for the development of natural analgesic drugs.
Article Details
Unique Paper ID: 163373

Publication Volume & Issue: Volume 10, Issue 11

Page(s): 854 - 858
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