ANTIMICROBIAL POTENTIAL OF NOVEL BENZOXAZINONE DERIVATIVES TETHERED WITH THIOSEMICARBAZONE SCAFFOLD

ANTIMICROBIAL POTENTIAL OF NOVEL BENZOXAZINONE DERIVATIVES TETHERED WITH THIOSEMICARBAZONE SCAFFOLD
Author(s):
PRIYADARSHINI MANDRU, DR. PABBA PARAMESHWAR
Keywords:

Abstract
Antibiotic resistance in bacterial pathogens has currently reached very high and alarming levels. Indeed, according to a number of international bodies, this “antibiotic resistance crisis” could possibly bring us back to a “pre-antibiotic era” in the near future, if no effective actions are promptly undertaken [1,2]. Unfortunately, the low success rate in antimicrobial agents’ discovery and development observed during the last decades has led to a limited availability of new compounds for clinical use, thus exacerbating the burden of antibiotic resistance on morbidity and mortality rates. In this scenario, also many modern clinical practices associated with an increased risk of infection and in which antibiotics are essential (e.g., anti-cancer treatments, solid organ and stem cell transplantations, or implantation of prosthetic devices) are seriously at risk of success [3].
Article Details
Unique Paper ID: 160825 Publication Volume & Issue: Volume 8, Issue 3 Page(s): 1141 - 1150
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