Development and Evaluation of a Novel Herbal Chewable Tablet for Tobacco and Smoking Cessation
Author(s):
Jainam Shah, Purva Patel, Subhash Chandra Patel, Dr. Vaishali Thakkar, Dr. Tejal Gandhi
Keywords:
Chewable tablet, Herbal formulation, Nicotine dependency, Tobacco and Smoking Cessation.
Abstract
Tobacco addiction is one of the leading causes of disabilities and mortality. Addicts struggle with nicotine addiction and withdrawal symptoms. This study aimed to develop and test herbal chewable tablets, taking into account their pharmacological properties as an herbal treatment for reducing nicotine dependence using Areca Nut and Cinnamon, and their identification was done by Thin Layer Chromatography (TLC) and in the case of Areca Nut Total, Phenolic Content was also carried out. Flow property of powder was found to be fair and poor compressibility of powder leads to the selection of the Wet Granulation method of Tablet preparation with Non-sugar sweetening agent Stevia and peppermint oil as flavoring agents. Initially, the fair flow property was enhanced in this study by comparing various granulation processes via different batches of Wet granulation using Lactose Monohydrate, Dry granulation using Pregelatinized Starch (Starch 1500), in Direct Compression using Microcrystalline cellulose powder (MCCP) and Polyvinylpyrrolidone (PVP) K30. The optimized formulation, i.e. batch with Lactose Monohydrate and PVP K30, was incorporated with varying concentrations of binders and the batch with 17% binder concentration showed the best results. Various post-compression parameters were evaluated for the prepared tablets. Tablets have been evaluated for weight variation test in which optimized batch showed results within pharmacopoeial limits, with 0.25% friability, with 2.25 kg/m2 hardness; the time required for complete chewing was found to be an acceptable limit. This preparation is a stable, solid dosage form, and it revealed that the composition ratio of ingredients of herbal tablets does not affect the stability parameters. This formulation was also compared with the other marketed chewable tablet formulation and showed all the required results necessary for chewable tablet formulation.
Article Details
Unique Paper ID: 154982

Publication Volume & Issue: Volume 8, Issue 12

Page(s): 924 - 932
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