REVIEW ON DIABETES MELLITUS
Author(s):
PRATIBHA R.VANNARWAD, AKSHATA B. LASURE, NANDKISHOR B.BAVAGE, SHYAMLILA B.BAVAGE
Keywords:
Diabetes mellitus,type 1diabetes mellitus, type 2 diabetes mellitus, gastational diabetes mellitus, insulin.
Abstract
Diabetes mellitus may be a cluster of metabolic diseases characterized by hyperglycemia ensuing from defects in hypoglycemic agent secretion, hypoglycemic agent action, or both. The chronic hyperglycemia of diabetes is associated with semi-permanent harm, dysfunction, and failure of varied organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Several unhealthful processes square measure concern with in the development of diabetes. These vary from autoimmune destruction of the beta-cells of the exocrine gland with ensuant insulin deficiency to abnormalities that lead to resistance to insulin action.. In the latter, class a degree of hyperglycemia enough to cause pathologic and purposeful changes in varied target tissues, However while not clinical symptoms, may be present for a long period of time before polygenic disease is recognize. Throughout this asymptomatic period, it is doable to demonstrate an abnormality in macromolecules metabolism by measure of plasma aldohexone in the fasting state or after a challenge with an oral aldohexone load.The degree of hyperglycemia (if any) could amendment over time, looking on the extent of the basic disease process . A illness method could also be gift however might not have progressed far enough to cause hyperglycemia. The same disease process can cause impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) while not fulfilling the standards for the diagnosis of polygenic disease . In some specific with diabetes, adequate glycemic control can be achieved with weight reduction, exercise, and/or oral aldohexone lowering agents. These individuals therefore do not require insulin. Other individuals who have some residual hypoglycemic agent secretion but require exogenous insulin for adequate glycemic control can survive without it. Individuals with extensive beta-cell destruction and therefore no residual insulin secretion need hypoglycemic agent for survival. The seriousness of the metabolic abnormality will progress, regress, or keep an equivalent. Thus, the degree of hyperglycemia reflects the severity of the underlying biological process and its treatment quite the character of the strategy itself.
Article Details
Unique Paper ID: 153243

Publication Volume & Issue: Volume 8, Issue 6

Page(s): 213 - 218
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