Comparative study of the crystal structures of 7,8-Dimethyl-4-bromomethylcoumarin (C12 H11 Br O2) and 7-methyl 6, 8-dinitro 4-bromomethyl coumarin (C11 H7 Br N2 O6)
Author(s):
Dr. Ramakrishna Gowda, Dr. K. V Arjuna Gowda
Keywords:
bromomethylcoumarin, Methoxycrystal x-ray study, Molecular Packing and hydrogen bonding
Abstract
4-Bromomethylcoumarins were first reported by Dey and co-workers by the reaction of various phenols and 4-bromoethylacetoacetate under Pechmann cyclisation conditions .Compounds have been used for the synthesis of a variety of ethers, amines, sulphides, bi- and tri-heterocycles which have been screened for anti-microbials, anti-inflammatory and analgesic activities Halomethylcoumarins were screened for their protease inhibiting property and due to the biochemical importance of 7-methoxy-4-bromomethylcoumarin is now commercially available. FT-IR-Raman spectral studies along with ab-initio calculations have indicated the existence of conformers which differ in their orientation with respect to the coumarin ring. It is likely that the allylic bromine (with respect to C3-C4 double bond) is oriented an angle of around 100o to the mean plane of the coumarin moiety. In view of this, it was thought of considerable interest to study the X-ray structures of various 4-bromomethylcoumarins with different groups in the benzene ring.
Article Details
Unique Paper ID: 154445

Publication Volume & Issue: Volume 8, Issue 11

Page(s): 172 - 175
Article Preview & Download


Share This Article

Join our RMS

Conference Alert

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024

Last Date: 15th March 2024

Call For Paper

Volume 10 Issue 10

Last Date for paper submitting for March Issue is 25 June 2024

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews