FORMULATION AND EVALUATION OF PRESS-COATED PULSATILE DELIVERY OF FLURBIPROFEN TABLETS
Author(s):
Bura Jayasree, Dr.Sridhar Babu Gummadi, Dr.L.Srikanth
Keywords:
Abstract
The objective of present study is to formulate and evaluation of press-coated pulsatile delivery of flurbiprofen tablets for treatment of rheumatoid arthritis. The press coated method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 4 hours. The design of the system consists of a rapid release core and controlled release coat. A combination of HPMC K 15M and eudragit RL 100, was used as a coating material for the tablet. The formulations (F1-F3) of the core were prepared by using crospovidone (CP) as disintegrants in different proportions (10%, 15% and 20%) to study the effect of variable concentrations of these on the characteristics of the formulation. Among these formulations, F1 containing CP (20%) as disintegrant showed a better drug release of 98% over 1hr was selected. The core was coated with of HPMC K 15M and eudragit RL100 with different polymer ratios (F1- F6). Among these, F6 was optimized formulation based on the lag time and percent of drug release (96% of drug release in 6 hours). Thus, compression coated tablets with a clear lag time before drug release is a potentially useful formulation for the treatment of rheumatoid arthritis.
Article Details
Unique Paper ID: 152644

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 1021 - 1025
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