INSULIN-LIKE GROWTH FACTOR AND PROSTATE CANCER RISK
Author(s):
Surajkumar Shivajirao Choukate, Shyamlila B. Bavage, Nandkishor B. Bavage
Keywords:
prostate cancer,insulin-like growth factor; insulin-like growth factor binding protein, meta-analysis.
Abstract
Insulin-like growth factors (IGF-I, IGF-II) and their binding proteins (IGFBP-1–6) important role in cell proliferation, differentiation and apoptosis, suggesting possible involvement in carcinogenesis. Several epidemiological studies show the associations of IGFs with prostate cancer .We searched the published literature for all studies related with the levels of IGFs with prostate cancer. We performed random effects meta-analysis to calculate the summary odd ratios. The number of studies (prostate cancer cases) included in each meta-analysis were 42 (7,481) IGF-I; 10 (923) IGF-II; 3 (485) IGFBP-1; 5 (577) IGFBP-2; 29 (6,541) IGFBP-3 and 11 (3,545) IGF-1: IGFBP-3 ratio. The pooled odds ratios (95%confidence intervals) per standard deviation increase in peptide were: IGF-I, OR 5 1.21 (1.07, 1.36); IGF-II, OR 5 1.17(0.93,1.47) IGFBP-1, OR 5 1.21 (0.62, 2.33); IGFBP-2, OR 5 1.18 (0.90, 1.54); IGFBP-3, OR 5 0.88 (0.79, 0.98); IGFI:IGFBP-3 ratio, OR 5 1.10 (0.97, 1.24).There was weak evidence that associations of the IGF-I and IGFBP-3 with prostate cancer were stronger for the advanced disease. Our meta-analysis confirms that the raised circulating lGF-I is positively associated with prostate cancer risk.
Article Details
Unique Paper ID: 152365

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 31 - 38
Article Preview & Download


Share This Article

Join our RMS



Conference Alert

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024

Last Date: 15th March 2024

Latest Publication

Call For Paper

Volume 10 Issue 10

Last Date for paper submitting for March Issue is 25 June 2024

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews

Contact Details

Telephone:6351679790
Email: editor@ijirt.org
Website: ijirt.org

Policies

Important Links

Browse Rsearch papers