Nanocrystals In Drug Delivery- A Review

Nanocrystals In Drug Delivery- A Review
Author(s):
Kalyani A. Ghadge, Ashwini A Pawar, Rupali B. Kewat, Aijaz A.Sheikh, Ravindra H. Kale, Kaiash R. Biyani
Keywords:
Nanocrystal, Drug delivery, Bioavailability, polymeric nanocrystals, techniques.
Abstract
Nanocrystals are the aggregates anywhere from a few hundred to tens of thousands of atoms that combine into a crystalline form of matter known as a “ Cluster “ .They are used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation. The method of preparations of nanocrystal is down, top down and bottom up, spray drying and so new techniques. There are several important advantages of nanocrystal formulation such as, enhanced oral bioavailability, improved dose proportionality, reduced food effects, suitability for administration by all routes and possibility of sterile filtration due to decreased particle size range. Selection depends upon the sites and to deliver the drug at a controlled sustained rate to the site of action. Here we review various aspects of nanocrystals in drug delivery and their pharmaceutical applications in drug delivery.
Article Details
Unique Paper ID: 153911 Publication Volume & Issue: Volume 8, Issue 9 Page(s): 462 - 469
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